TABLE OF CONTENTS Introduction page Chapter 1 General introduction, aim and outline of thesis 9 Perceived intra-oral dryness Chapter 2 Regional differences in perceived oral dryness as determined with a newly developed questionnaire, the Regional Oral Dryness Inventory 27 Chapter 3 Differences in perceived intra-oral dryness in various dry-mouth patients as determined using the Regional Oral Dryness Inventory 47 Intra-oral surfacea area and salivary distribution Chapter 4 Determination of intra-oral surface areas by cone-beam computed tomography analysis and their relation with anthropometric measurements of the head 77 Chapter 5 Correlations of palatal surface area with anthropometric dimensions of head and face 95 Chapter 6 Salivary film thickness and MUC5B levels at various intra-oral surfaces 111 Interventions to relieve oral dryness Chapter 7 The relationship between the severity of oral dryness and the use of dry-mouth interventions by various subgroups of dry-mouth patients 137 Chapter 8 The association between oral dryness and use of dry-mouth interventions in Sjögren’s syndrome patients 161 Chapter 9 Preferences of Sjögren’s syndrome patients regarding potential new saliva substitutes 185 Discussion and summary Chapter 10 General discussion 205 Chapter 11 Summary 217 Chapter 12 Nederlandse samenvatting 223 Appendices 229 Contributions of the authors 230 Acknowlegdements 233 About the author 236 List of publications 237
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