141 Ventriculomegaly and TH | Crouzon Table 3. Mixed-model for tonsil position 95% CI Estimate 2.5% 97.5% (Intercept) -11.616 -17.882 -6.232 Age at measurement § FOHR: Per 10% increase +1.597 +0.410 +3.047 Head circumference‡ -0.424 -1.569 +0.303 Closed lambdoid sutures< 1 year +6.990 +3.614 +10.276 Expected tonsil position at 0 and 5 years by specific covariate values* FOHR Expected tonsil position 95% CI Age 0 Q1: 0.33 -6.558 -9.048 -4.020 Q3: 0.41 -5.279 -7.233 -3.088 Age 5 Q1: 0.33 +1.518 +0.190 +3.185 Q3: 0.41 +2.798 +1.347 +4.597 Head-circumference‡ Age 0 Q1: -0.66 -5.431 -7.459 -3.120 Q3: 1.39 -6.295 -9.017 -3.648 Age 5 Q1: -0.66 +2.646 +0.929 +4.801 Q3: 1.39 +1.781 +0.269 +3.517 Closed lambdoid sutures< 1 year Age 0 Open -5.920 -8.086 -3.585 Closed +1.079 -2.497 +4.496 Age 5 Open +2.157 +0.878 +3.806 Closed +9.156 +6.105 +12.155 CI: Credible interval, FOHR: fronto-occipital horn ratio, Q1: 1st quartile in observed data, Q3: 3rd quartile in observed data Values represent tonsil position in mm relative to the foramen magnum, where tonsillar herniation past the foramen magnum is represented as positive numbers, and a position above the foramen magnum as negative numbers. § The non-linear effect of age at measurement was used in the model, but cannot be represented by a single parameter estimate and the corresponding estimates do not have direct clinical interpretation ‡ in SD * The other covariates were set to reference/median values (FOHR: 0.37, head circumference: 0.51 SD, lambdoid sutures: open) 8
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