161 Clinical Course | Crouzon AN CONCLUSIONS In summary, patients with the mutation c.1172C>A (p.Ala391Glu) in the FGFR3 gene follow a severe clinical course with numerous interventions. The timing and order of interventions changed among patients and centers. It was not possible to differentiate the effect of a more severe clinical presentation from the effect of treatment order on outcome. This study further supports a comparison of different treatment philosophies, in which larger sample numbers and a structured multidisciplinary follow-up are required. 9
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