38 Chapter 2 RESULTS Characteristics A total of 36 patients with trigonocephaly with a median age of 0.50 years (IQR 0.30) and sixteen control subjects with a median age of 0.83 years (IQR 0.56) were included (Table 1). The age was shown to be significantly different (p = 0.006) between patients (mean: 0.60 years) and controls (mean: 0.90 years). Sex was also significantly different between groups (p = 0.03) but had no significant effect on the frontal lobe perfusion in this cohort (p = 0.09). Table 1. Patient characteristics Trigonocephaly (n=36) Controls (n=16) Sex (n female) 11 (30.6%) 10 (62.5%) Age (median± IQR years) 0.50±0.30 0.83±0.56 Quantitative Comparison of Normalization Strategies From all normalization strategies, regASLdct shows the highest TC score (Figure 1). The range of the TC is depicted for patients and controls in Figure 2. The overlapping boxplots of the ASL normalization types in the control group, demonstrate that there is little difference between these normalizations with respect to the TC. RegASLdct had the highest TC outcome for patients as well as controls. For patients, regASLaffine had better TC outcomes than regT1, or regASLrigid, whereas for controls regASLrigid performed similar to regASLaffine. Figure 1. A scatterplot of the Tanimoto coefficient of four registration types of the total cohort in time (age in years).
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