INDEX Chapter 1 General introduction 10 Part 1 Brain imaging in non-operated infants with isolated and syndromic craniosynostosis Chapter 2 Using perfusion contrast for spatial normalization of ASL MRI images in a pediatric craniosynostosis population 32 Chapter 3 Cerebral blood flow of the frontal lobe in untreated children with trigonocephaly vs healthy controls - an arterial spin labeling study 50 Chapter 4 Reply: discussion cerebral blood flow of the frontal lobe in untreated children with trigonocephaly versus healthy controls: an arterial spin labeling study 64 Chapter 5 A diffusion tensor imaging analysis of frontal lobe white matter microstructure in trigonocephaly patients 70 Chapter 6 A diffusion tensor imaging analysis of white matter microstructures in non-operated craniosynostosis patients 92 Part 2 Brain imaging during follow-up of operated children with isolated and syndromic craniosynostosis Chapter 7 Cortical thickness in Crouzon-Pfeiffer syndrome: findings in relation to primary cranial vault expansion 110 Chapter 8 The course and interaction of ventriculomegaly and cerebellar tonsillar herniation in Crouzon syndrome over time 130 Chapter 9 Clinical signs, interventions, and outcomes of three different treatment protocols in patients with Crouzon syndrome and acanthosis nigricans 150 Chapter 10 General discussion 166 Chapter 11 Summary 180 Chapter 12 Nederlandse samenvatting 186 Appendices List of publications 193 PhD portfolio 194 Curriculum vitae 197 Dankwoord 198
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