65 Reply of the fMRI results. Finding a difference in connectivity in fMRI studies would be at the same level of evidence as the ASL brain MRI study.9 To conclude, our study further supports our hypothesis that surgery for trigonocephaly is rarely indicated functionally. Parents should be informed about the unknown added value of surgery regarding raised intracranial pressure and brain perfusion. Comparative research on outcome of conservative versus surgical treatment of moderate to severe trigonocephaly is needed to establish clinical guidelines. 4
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