86 Chapter 5 analysis of global or regional gray and white matter structures or cortical microstructure analysis, might improve our understanding of the pathophysiology of metopic synostosis and its possible relation to altered neural development. For the future, the comparison of brain properties of older operated patients with trigonocephaly with brain properties of older nonoperated patients with trigonocephaly could give more information about the substrate of the cognitive and behavioral issues and the added value of surgery. CONCLUSION In conclusion, microstructural parameters of white matter tracts of the frontal lobe of patients with trigonocephaly are comparable to those of controls aged 0-3 years. No difference in FA or MD of the frontal lobe white matter microstructure in trigonocephaly was found.
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