97 Microstructures | Syndromic Craniosynostosis craniosynostosis group in 5 subgroups (Apert, Crouzon, Muenke, Saethre-Chotzen and Complex). Each group was separately compared with the control group. RESULTS Patient characteristics Fifty-one non-operated sCS patients with a median age of 0.40 [IQR0.25] years were included, which involved Apert (n =8), Crouzon-Pfeiffer (n =14), Muenke (n = 8), and Saethre-Chotzen (n = 10) syndromes, and complex craniosynostosis (n = 11). Seventeen control subjects were included with a median age of 1.20 [IQR 0.85] years (Table 1). The measured tracts are visualized in Figure 1. Table 1. Patient Characteristics Apert CrouzonMuenke SaethreComplex Total patients Controls Pfeiffer Chotzen no. of subjects 14 8 10 11 51 17 M/F sex 4/4 5/9 1/7 5/5 2/9 17/34 5/12 Median age (IQR) 0.28 (0.07) 0.59 (0.37) 0.36 (0.13) 0.50 (0.22) 0.39 (0.22) 0.40 (0.25) 1.20 (0.85) Figure 1. Tractography: midsegment of bilateral corticospinal tracts (CST) and midsagittal views of the corpus callosum, medial cerebellar peduncle (MCP), fornix, cingulum hippocampal segment and cingulum body in a control patient. 6
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