99 Microstructures | Syndromic Craniosynostosis 1a. 1b. Figure 2. Ellipsoids of the mean ʎ1, ʎ2 and ʎ3 in two tracts: 1a. Corpus Callosum Genu and 1b. Cingulate Bundle Hippocampal Left Radial diffusivity analyses Since the genu of the corpus callosum and the hippocampal segment of the left cingulum bundle show a ƞ2 >0.14 in ʎ 2 and ʎ3, subsequent analyses focused on RD (see Table 3). By linear regression we found no significant effect of having syndromic craniosynostosis on RD in the corpus callosum genu and the hippocampal segment of the left cingulate bundle (p = 0.60 and p=0.78). The effect of age was significant for both tracts (p<0.025). A rise of 0.1 FOHR gives a rise of 0.15 x 10-3 mm2/sec in RD for the corpus callosum genu (95% CI 0.1 x 10-3 – 0.2 x 10-3 mm2/sec, p<0.025) and a rise of 0.07 x 10-3 mm2/sec for the hippocampal segment of the left cingulate bundle (95% CI 0.03 x 10-3 – 0.10 x 10-3 mm2/sec, p = .000). The effect of gender and the effect of tract volume were not significant on the RD values in the two assessed tracts. In the supplemental table 1 and 2, subsequent linear regressions based on type of syndrome are depicted. None of the specific syndromes in both linear regressions, on RD of the corpus callosum genu and on RD of the hippocampal segment of the left cingulate bundle, showed to be significantly different compared to the control group. 6
RkJQdWJsaXNoZXIy MTk4NDMw