The MoCA with a double threshold 5 117 or TIA (n=174). The patients suspected of having cognitive impairment after the initial assessment were referred to our memory clinic (n=290) (figure 1). All of these patients underwent a comprehensive cognitive diagnostic route for cognitive impairment using a consensus-based diagnosis, following international criteria as a reference standard with an NPA and when applicable, CT/MRI- imaging and cerebrospinal fluid (CSF) analysis (CBO Geriatrie, 2014). They were classified as MD, MCI (including psychiatric aetiologies) or NoCI (including subjective complaints, mostly psychiatric patients without objective cognitive impairment). For the strategic selection route comparison, we included all eligible referred patients (n=693), including those not suspected of cognitive impairment (n=403). The latter were followed for at least 2 years to compensate for not having an NPA to exclude conversion to any DSM IV/5 (American Psychiatric Association, 2000, 2013) cognitive diagnoses after the initial assessment. Three of them were diagnosed with cognitive impairment during follow-up and were considered inconclusive as it is not certain if these impairments manifested before or after initial assessment. To be conservative, we classified these three as FN MD. All participants gave their informed consent. Data are available upon request.
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