The MoCA with a double threshold 5 121 be referred (figure 1; column A, E), those who were to be observed (B, F), who were not (C, G) and the reference diagnoses (D). As the purpose of the study is to reduce the number of FP referrals without discharge a MD patient, we considered the observed MD, MCI and NoCI as TP, TN and TN, respectively. The calculation of the indicators for the two-stage strategy included the effects of the initial assessment (e.g. adding the 400TN and 3*FN to columns E, F, G). Table 2. Area Under the Curve between variations of groups and their sensitivity and specificity at cut-off scores 26 and 21, often used in literature. Stand-alone (n=693) or add-on (n=290). groups AUC SD Cutoff <26 Cutoff <21 Sens Spec Sens Spec MD vs NoDem (n=693) .865 .018 .975 .292 .901 .740 MD vs NoDem (n=290) .830 .026 .975 .173 .901 .654 MD vs MCI (n=693) .810 .029 .975 .065 .901 .627 MD vs MCI (n=290) .810 .029 .975 .065 .901 .627 CI vs NoCI (n=693) .765 .018 .949 .368 .556 .778 CI vs NoCI (n=290) .770 .040 .949 .473 .556 .727 MCI vs NoCI (n=693) .702 .022 .935 .368 .373 .778 MCI vs NoCI (n=290) .707 .048 .935 .473 .373 .727 MD: Mild Dementia; NoDem: No Dementia (MCI+NoCI); MCI: Mild Cognitive impairment; NoCI: Referred patients no Cognitive Impairment; CI; Cognitive Impairment (Dem + MCI). Stand-alone (n=693): all referred patients without judgement of initial assessment. Add-on (n=290): only those patients suspected of CI after initial assessment. All referred to memory clinic. 5.3 Results 5.3.1 Demographic findings The main demographic and clinical characteristics of the study group are listed in table 1. The significant differences in age and sex are representative of the demographics of an old age psychiatry setting and are substantiated elsewhere (Dautzenberg et al., 2020). The GAF score was the highest in the MCI group, as expected because these patients have the least severe symptoms, given the high number of MCI patients without any other psychiatric conditions (50%), whereas almost all patients in the NoCI had one or more psychiatric diagnoses (Dautzenberg et al., 2020).
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