104 Chapter 4 Table 3: The—univariable—effect of clinico-histopathological characteristics on disease-free survival and overall survival of patients diagnosed with cancers positive for transmembranous C-terminal MET with or without the ectodomain. Explanatory variable No. of patients Disease-free survival Overall survival # % HR 95% CI P value HR 95% CI P value Sex Male 68 64 Female 38 36 1.42 0.83–2.44 0.201 1.23 0.69–2.19 0.484 Age at diagnosisa Mean (range) 62.6 34.0–87.0 1.31 1.02–1.67 0.032 1.27 0.98–1.64 0.066 Smoking No 43 41 Yes 62 58 1.10 0.63–1.91 0.734 1.27 0.70–2.30 0.431 Missing 1 1 Alcohol No 77 73 Yes 29 27 1.12 0.63–2.01 0.698 0.97 0.51–1.83 0.921 Subsite Alveolus and gingiva 8 8 0.793 0.633 Lip 2 2 1.83 0.19–17.60 0.601 1.94 0.20–18.67 0.566 Tongue 45 42 1.20 0.36–4.03 0.772 0.92 0.27–3.14 0.887 Floor of mouth 34 32 1.52 0.45–5.15 0.498 1.48 0.44–5.01 0.528 Buccal mucosa 17 16 1.79 0.50–6.41 0.374 1.42 0.38–5.23 0.603 pT category pT1 17 16 0.309 0.064 pT2 44 42 1.61 0.65–3.98 0.306 2.98 0.88–10.07 0.079 pT3 12 11 1.97 0.66–5.86 0.224 3.59 0.90–14.34 0.071 pT4 33 31 2.30 0.92–5.74 0.074 4.84 1.44–16.31 0.011
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