106 Chapter 4 Table 3: (Continued) Explanatory variable No. of patients Disease-free survival Overall survival # % HR 95% CI P value HR 95% CI P value Extranodal extensiond Absent or pN0 81 76 Yes 24 23 3.51 1.99–6.19 0.000 3.67 2.04–6.66 0.000 Missing 1 1 Depth of infiltration ≤10 mm 40 38 >10 mm 65 61 1.87 1.04–3.35 0.036 2.06 1.09–3.90 0.026 Missing 1 1 Degree of differentiation Well 2 2 0.082 0.066 Moderate 80 75 0.30 0.07–1.24 0.096 0.74 0.10–5.42 0.767 Poor 22 21 0.46 0.10–2.03 0.302 1.37 0.18–10.5 0.760 Undifferentiated 2 2 1.13 0.16–8.05 0.902 3.58 0.32–39.7 0.299 Degree of differentiation in three categories Good 2 2 0.085 0.080 Moderate 80 75 0.30 0.07–1.25 0.097 0.74 0.10–5.42 0.767 Poor 24 23 0.50 0.11–2.19 0.355 1.50 0.20–11.3 0.697 Degree of differentiation dichotomous Well-moderate 82 77 Poor-undifferentiated 24 23 1.61 0.89–2.92 0.119 2.01 1.09–3.70 0.026 Growth pattern Cohesive 17 16 Noncohesive 89 84 1.21 0.57–2.57 0.614 1.50 0.64–3.54 0.350
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