107 MET ECD shedding and poor DFS Table 3: (Continued) Explanatory variable No. of patients Disease-free survival Overall survival # % HR 95% CI P value HR 95% CI P value Perineural invasion No 52 49 Yes 48 45 0.87 0.50–1.51 0.614 0.93 0.52–1.68 0.811 Missing 6 6 Lymphovascular invasion (assuming ≥ pN1 and histologically observed) No 47 44 Yes 56 53 1.33 0.77–2.31 0.306 1.56 0.86–2.82 0.143 Missing 3 3 Lymphovascular invasion (histologically observed) No 83 78 Yes 21 20 1.51 0.81–2.83 0.198 1.86 0.98–3.54 0.059 Missing 2 2 Bone invasion Absent or no bone present 82 77 Present 24 23 1.08 0.57–2.04 0.824 1.29 0.67–2.48 0.443 Treatment Surgery 31 29 Surgery and radiotherapy 75 71 1.35 0.72–2.52 0.345 1.71 0.85–3.44 0.131 aThe HR was based on 10 year intervals bBased on pTNM, which was assessed according to the 7th edition of the AJCC cAll included patients are assessed as pM = 0 by clinical and/or histological examination dAssessed by histological examination 4
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