125 MET ECD shedding and poor DFS Supplementary table 5: Possible MET N- and C-terminal fragments. N-terminal MET protein fragments C-terminal MET protein fragments Mw (kDa) Non-reducing Mw (kDa) reducing conditions Membrane spanning Protein fragment Ref. Mw (kDa) reducing conditions Membrane spanning Protein fragment Ref. Information not found p50β No Soluble N-terminal truncated β-chain which is shed from the membrane; no tyrosine kinase activity (6) p95β Yes Theoretical counterpart of corresponding N-terminal fragment N/A* Information not found p55β No Soluble N-terminal truncated β-chain which is shed from the membrane; no tyrosine kinase activity (6) p90b Yes Theoretical counterpart of corresponding N-terminal fragment N/A p130 p75β No Soluble N-terminal truncated β-chain which is shed from the membrane; no tyrosine kinase activity (4, 6) p70β Yes Theoretical counterpart of corresponding N-terminal fragment N/A p140 p85β Yes Membrane spanning N-terminal truncated β-chain; no tyrosine kinase activity (4, 6) p60β Yes Theoretical counterpart of corresponding N-terminal fragment N/A Information not found Information not found Information not found Information not found N/A p55β Yes Intracellular domain of MET (7) Information not found Information not found Information not found Information not found N/A p50b No Possible C-terminal fragment resulting after ectodomain shedding (8) Information not found p100β Yes Theoretical counterpart of corresponding C-terminal fragment (9) p40b No Proapoptotic intracellular 40 kDa C-terminal fragment (10, 11) * N/A: not applicable. 4
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