126 Chapter 4 Supplementary table 6: The – univariable – effect of MET receptor status on disease free survival using Cox regression analysis. MET receptor status Number Percentage HR 95% CI P-value Transmembranous C-terminal MET with or without the ectodomain 106 68 0.035 Decoy receptor 14 9 1.23 0.61 – 2.49 0.567 Uniform negative 36 23 1.84 1.16 – 2.93 0.010 Chi-square test: P=0.032 Supplementary table 7: The – univariable – effect of MET receptor status on overall survival using Cox regression analysis. MET receptor status Number Percentage HR 95% CI P-value Transmembranous C-terminal MET with or without the ectodomain 106 68 0.016 Decoy receptor 14 9 1.47 0.72 – 2.99 0.291 Uniform negative 36 23 2.00 1.24 – 3.23 0.005 Chi-square test: P=0.014 Supplementary table 8: Results of performed receiver operating characteristic curve analyses in view of determining the cut off for percentage of cancer cells subjective to ectodomain shedding in view of survival analyses for disease free survival for patients with transmembranous C-terminal MET positive cancers using Youden’s J statistic. Area Std. error Asymptotic sig. Asymptotic 95% confidence interval Lower bound Upper bound Results receiver operating characteristic curve used to determine the maximal value of the Youden index to determine the optimal cut-off for % of cancer cells subjective to ectodomain shedding in view of survival analyses 0.61 0.055 0.056 0.50 0.72 Results receiver operating characteristic curve obtained using the optimal cut off of 35.667% of cancer cells subjective to ectodomain shedding 0.62 0.055 0.039 0.51 0.72
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