127 MET ECD shedding and poor DFS Supplementary table 9: Sensitivity, specificity, positive and negative predictive value, accuracy and area under the curve of MET ectodomain shedding in view of survival analyses with respect to disease free survival for patients with transmembranous C-terminal MET positive cancers. Positive test result was set at ≥ 35.667% ectodomain shedding Sensitivity (%) Specificity (%) PPV (%) NPV (%) Accuracy (%) Area under the curve (95% CI) Cancers positive for transmembranous C-terminal MET 46.30 76.92 67.57 57,97 61.32 0.62 (0.51; 0.72) Supplementary table 10: Results of performed receiver operating characteristic curve analyses in view of determining the cut off for percentage of cancer cells subjective to ectodomain shedding in view of survival analyses for overall survival for patients with transmembranous C-terminal MET positive cancers using Youden’s J statistic. Area Std. error Asymptotic sig. Asymptotic 95% confidence interval Lower bound Upper bound Results receiver operating characteristic curve used to determine the maximal value of the Youden index to determine the optimal cut-off for % of cancer cells subjective to ectodomain shedding in view of survival analyses 0.61 0.056 0.061 0.50 0.72 Results receiver operating characteristic curve obtained using the optimal cut off of 35.667% of cancer cells subjective to ectodomain shedding 0.60 0.056 0.078 0.49 0.71 Supplementary table 11: Sensitivity, specificity, positive and negative predictive value, accuracy and area under the curve of MET ectodomain shedding in view of survival analyses with respect to overall survival for patients with transmembranous C-terminal MET positive cancers. Positive test result was set at ≥ 35.667% ectodomain shedding Sensitivity (%) Specificity (%) PPV (%) NPV (%) Accuracy (%) Area under the curve (95% CI) Cancers positive for transmembranous C-terminal MET 45.83 74.14 59.46 62.32 61.32 0.60 (0.49; 0.71) 4
RkJQdWJsaXNoZXIy MTk4NDMw