135 MET ECD shedding and poor DFS Supplementary figure 8: Receiver operating characteristic curves used to determine the cut off 35% of cancer cells subjective to shedding in view of survival analyses for overall survival for cancers positive for transmembranous C-terminal MET. A. Receiver operating characteristic curve used to determine the maximal value of the Youden index – indicated with the red dashed line – to determine the optimal cut-off for % of cancer cells subjective to shedding in view of survival analyses (P=0.061). B. Results for the receiver operating characteristic curve obtained using the optimal cut off of 35.67% of cancer cells subjective to shedding (P=0.078). 4
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