146 Chapter 5 Table 1: Baseline characteristics for the entire sample population (n=203). Clinico-histopathological characteristic No. of patients # % Sex Male 115 56.7 Female 88 43.3 Age at diagnosis Mean (range) 63.6 (26.0 – 95.0) Subsite Mucosa of lip 1 0.50 Other and unspecified parts of tongue 100 49.3 Alveolus and gingiva 21 10.3 Floor of mouth 54 26.6 Palate 2 1.00 Other and unspecified parts of mouth 25 12.3 Cancer stage*, ** I 57 28.1 II 33 16.3 III 30 14.8 IV 74 36.5 Missing 9 4.40 Treatment Surgery 104 51.2 Surgery and radiotherapy 99 48.8 * Based on pTNM, which was assessed according to the 7th edition of the AJCC. ** All included patients are assessed as pM=0 by clinical and/or histological examination. Intra antibody comparison of staining patterns Examination of the distributions of the observed staining patterns obtained as per antibody shows that the D1C2 uniform staining patterns – negative or positive – are more often observed across smaller patches and that the gradient toward the periphery staining pattern tends to cover bigger patches (Supplementary figures 3A through D). It also shows that A2H2-3 immunoreactivity is frequently completely absent (n = 63, 31.0%), is rarely completely positive (n = 4, 2.0%) and displays relatively smaller patches of gradient toward the periphery (Supplementary figures 3E through H). Finally, it shows that the NCH-38 uniform negative staining pattern is more often observed across smaller patches, the complete uniform positive staining pattern is often absent (n = 117, 58.0%), and – if present – the gradient toward the
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