Martine De Herdt

162 Chapter 5 Supplementary tables Supplementary table 1: Results of the performed ROC curve analyses in terms of determining which staining patters are associated with OS for patients positive for TM C-terminal MET in the gradient towards periphery and/or uniform positive staining pattern (n=152). Antibody Staining pattern Area Std. error Asymptotic sig. Asymptotic 95% confidence interval Lower bound Upper bound D1C2 Uniform negative 0.52 0.048 0.642 0.43 0.62 Uniform positive 0.62 0.046 0.012 0.53 0.71 Gradient towards periphery* 0.57 0.047 0.123 0.48 0.67 A2H2-3 Uniform negative 0.51 0.048 0.823 0.42 0.61 Uniform positive 0.53 0.048 0.525 0.44 0.62 Gradient towards periphery* 0.53 0.049 0.593 0.43 0.62 NCH-38 Uniform negative 0.61 0.047 0.017 0.52 0.71 Uniform positive* 0.51 0.048 0.797 0.42 0.61 Gradient towards center* 0.57 0.047 0.145 0.48 0.66 * Test direction: a smaller test result indicates a more positive test result; death. Supplementary table 2: Results of the performed ROC curve analyses in terms of determining which staining patters are associated with DFS for patients positive for TM C-terminal MET in the gradient towards periphery and/or uniform positive staining pattern (n=152). Antibody Staining pattern Area Std. error Asymptotic sig. Asymptotic 95% confidence interval Lower bound Upper bound D1C2 Uniform negative 0.55 0.047 0.343 0.45 0.64 Uniform positive 0.62 0.046 0.008 0.53 0.71 Gradient towards periphery* 0.61 0.046 0.017 0.52 0.70 A2H2-3 Uniform negative 0.54 0.047 0.378 0.45 0.63 Uniform positive 0.54 0.047 0.444 0.44 0.63 Gradient towards periphery* 0.57 0.046 0.122 0.48 0.66 NCH-38 Uniform negative 0.60 0.046 0.044 0.50 0.69 Uniform positive 0.51 0.047 0.903 0.41 0.60 Gradient towards center* 0.57 0.047 0.129 0.48 0.66 * Test direction: a smaller test result indicates a more positive test result; not disease-free or death.

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