163 MET, ECD shedding, and loss of E-cadherin Supplementary table 3: Results of the performed ROC curve analyses in terms of determining if MET ECD shedding in the gradient towards periphery and/or uniform positive staining pattern is associated with OS for patients positive for TM C-terminal MET in the gradient towards periphery and/or uniform positive staining pattern (n=152). Staining pattern Area Std. error Asymptotic sig. Asymptotic 95% confidence interval Lower bound Upper bound Gradient towards periphery* 0.57 0.047 0.121 0.48 0.67 Uniform positive 0.62 0.047 0.011 0.53 0.71 * Test direction: a smaller test result indicates a more positive test result; death. Supplementary table 4: Results of the performed ROC curve analyses in terms of determining if MET ECD shedding in the gradient towards periphery and/or uniform positive staining pattern is associated with DFS for patients positive for TM C-terminal MET in the gradient towards periphery and/or uniform positive staining pattern (n=152). Staining pattern Area Std. error Asymptotic sig. Asymptotic 95% confidence interval Lower bound Upper bound Gradient towards periphery* 0.56 0.047 0.243 0.46 0.65 Uniform positive 0.62 0.046 0.011 0.53 0.71 * Test direction: a smaller test result indicates a more positive test result; not disease-free or death. 5
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