171 MET, ECD shedding, and loss of E-cadherin Supplementary table 21: The – univariable – effect of clinico-histopathological characteristics on OS and DFS of patients diagnosed with cancers positive for TM C-terminal MET with or without the ECD (n=152). Explanatory variable No. of patients OS DFS # % HR 95% CI P-value HR 95% CI P-value Sex Male 80 52.6 Female 72 47.4 1.24 0.76 – 2.04 0.39 1.31 0.84 – 2.05 0.23 Age at diagnosis* Mean (range) 62.8 (27.0 – 95.0) 1.37 1.13 – 1.65 0.001 1.29 1.09 – 1.53 0.003 Subsite Alveolus and gingiva 13 8.55 0.49 0.73 Mucosa of lip 1 0.66 4.45 0.50 – 40.1 0.18 3.20 0.37 – 27.5 0.29 Other and unspecified parts of tongue 88 57.9 1.30 0.46 – 3.69 0.62 1.42 0.56 – 3.57 0.46 Floor of mouth 35 23.0 1.82 0.61 – 5.42 0.28 1.69 0.64 – 4.51 0.29 Other and unspecified parts of mouth 15 9.87 1.82 0.55 – 6.05 0.33 1.74 0.58 – 5.19 0.32 Subsite_v2 Alveolus and gingiva, Mucosa of lip, other and unspecified parts of mouth 29 19.1 0.54 0.79 Other and unspecified parts of tongue 88 57.9 0.87 0.45 – 1.65 0.66 0.99 0.55 – 1.78 0.97 Floor of mouth 35 23.0 1.21 0.59 – 2.49 0.61 1.18 0.61 – 2.31 0.62 pT category dichotomous pT1 60 39.5 ≥ pT2 87 57.2 1.70 0.99 – 2.94 0.057 1.28 0.80 – 2.03 0.31 Missing 5 3.29 5
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