173 MET, ECD shedding, and loss of E-cadherin Supplementary table 21: (Continued) Explanatory variable No. of patients OS DFS # % HR 95% CI P-value HR 95% CI P-value Perineural invasion No 145 95.4 Yes 6 3.95 1.71 0.62 – 4.72 0.30 1.33 0.49 – 3.64 0.58 Missing 1 0.66 Lymphovascular invasion (assuming ≥ pN1 and histologically observed) No 104 68.4 Yes 47 30.9 1.46 0.87 – 2.47 0.15 1.12 0.69 – 1.81 0.66 Missing 1 0.66 Lymphovascular invasion (histologically observed) No 148 97.4 Yes 3 1.97 0.80 0.11 – 5.79 0.83 0.56 0.077 – 3.99 0.56 Missing 1 0.66 Bone invasion Absent OR no bone present 137 90.1 Present 14 9.21 0.84 0.33 – 2.08 0.70 0.78 0.34 – 1.78 0.55 Missing 1 0.66 Treatment Surgery 81 53.3 Surgery and radiotherapy 71 46.7 1.61 0.98 – 2.65 0.062 1.07 0.69 – 1.67 0.76 * The HR was based on 10 year intervals. ** Based on pTNM, which was assessed according to the 7th edition of the AJCC. *** All included patients are assessed as pM=0 by clinical and/or histological examination. **** Assessed by histological examination. 5
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