174 Chapter 5 Supplementary table 22: Comparison of the HRs obtained for D1C2 uniform positivity and ECD shedding for C-terminal MET positive cancers between WTSs and the TMA for OS. WTSs (n=152) TMA (n=106) HR 95% CI P-value HR 95% CI P-value D1C2 uniform positivity No Yes 2.40 1.25 – 4.61 0.008 2.33 1.32 – 4.14 0.004 ECD shedding No Yes 2.30 1.38 – 3.83 0.001 1.83 1.04 – 3.23 0.038 Supplementary table 23: Comparison of the HRs obtained for D1C2 uniform positivity and ECD shedding for C-terminal MET positive cancers between WTSs and the TMA for DFS. WTSs (n=152) TMA (n=106) HR 95% CI P-value HR 95% CI P-value D1C2 uniform positivity No Yes 1.83 1.07 – 3.14 0.027 1.85 1.07 – 3.20 0.028 ECD shedding No Yes 1.87 1.19 – 2.92 0.006 2.05 1.20 – 3.51 0.009 Supplementary table 24: Cross tabulation showing the number and percentage of D1C2 uniform positive cancers per pathological cancer stage for C-terminal MET positive cancers. Pathological cancer stage* Not D1C2 uniform positive (< 10%) D1C2 uniform positive (≥ 10%) Total # % # % # % I 18 37.5 30 62.5 48 100 II 9 37.5 15 62.5 24 100 III 6 23.1 20 76.9 26 100 IV 13 27.1 35 72.9 48 100 Chi-square test: P=0.477 * Based on pTNM, which was assessed according to the 7th edition of the AJCC. Supplementary table 25: Cross tabulation showing the number and percentage of MET shedding status per pathological cancer stage for C-terminal MET positive cancers. Pathological cancer stage* No shedding (< 10%) Shedding (≥ 10%) Total # % # % # % I 28 58.3 20 41.7 48 100 II 14 58.3 10 41.7 24 100 III 15 57.7 11 42.3 26 100 IV 25 52.1 23 47.9 48 100 Chi-square test: P=0.922 * Based on pTNM, which was assessed according to the 7th edition of the AJCC.
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