176 Chapter 5 Supplementary figure 3: Bar charts and box plots representing the distributions of the D1C2, A2H2-3 and NCH-38 staining patterns that differ significantly* from one another according to the Kruskal-Wallis Test** (P<0.000). Subsequent pairwise analyses using the Mann-Whitney U Test** show (1) statistical significance for all possibilities for D1C2 and A2H2-3 and (2) between both uniform – negative or positive – and the gradient towards center staining pattern for NCH-38. A. The distribution of the uniform negative staining pattern is J-shaped, implying that generally no or small patches of negativity are observed. Yet, also implying that a considerable proportion of the stainings show no immunoreactivity for D1C2. B. The distribution of the D1C2 uniform positive staining pattern is skewed to the right, implying that no or small patches of this staining pattern are frequently observed. C. The distribution of the D1C2 gradient towards periphery staining pattern is U shaped, implying that this pattern is more likely to be absent or present across the entire cancer. D. Box plot illustrating statistical significance between the medians of the scores observed per staining pattern. Before performing pairwise-comparison, it was established that the medians of the scores across the 3 categories – uniform negative (15.0%), uniform positive (10.0%) and gradient towards
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