177 MET, ECD shedding, and loss of E-cadherin periphery (40.0%) – differ significantly according to the Median Test** (P<0.000). E. The distribution of the A2H2-3 uniform negative staining pattern is skewed to the left, implying that large patches of the uniform negative staining pattern or complete absence of A2H2-3 immunoreactivity frequently occur. F. The distribution of the A2H2-3 uniform positive staining pattern is skewed to the right, implying that no or small patches of this staining patterns are frequently observed. G. The distribution of the A2H2-3 gradient towards periphery staining pattern is skewed to the right, implying that no or small patches of this staining patterns are frequently observed. H. Box plot illustrating statistical significance between the medians of the scores observed per staining pattern. Before performing pairwise-comparison, it was established that the medians of the scores across the 3 categories – uniform negative (65.0%), uniform positive (5.0%) and gradient towards periphery (20.0%) – differ significantly according to the Median Test** (P<0.000). I. The distribution of the NCH-38 uniform negative staining pattern is skewed to the right, implying that no or small patches of this staining patterns are frequently observed. J. The distribution of the A2H2-3 uniform positive staining pattern is skewed to the right, implying that no or small patches of this staining patterns are frequently observed. K. The distribution of the NCH-38 gradient towards center staining pattern is U shaped, implying that this pattern is more likely to be absent or present across the entire cancer. L. Box plot illustrating statistical significance between the medians of the scores observed per staining pattern. Before performing pairwise-comparison, it was established that there was a significant difference between the medians of the scores across the 3 categories – uniform negative (10.0%), uniform positive (0.00%) and gradient towards center (70.0%) – according to the Median Test** (P<0.000). * Statistical significance was set at P<0.05. ** Calculations were performed with SPSS Statistics (version 25; IBM; Armonk, NY, USA). 5
RkJQdWJsaXNoZXIy MTk4NDMw