194 Chapter 6 Table 2: cross-tabulations showing the relationship between MET positivity and pN status in all cancers (n=102) and in cN0 cancers (n=90). MET positivity All patients (n=102) cN0 patient (n=90) pN+ pN0 Row total pN+ pN0 Row total Yes 20 (66.7%) 25 (34.7%) 45 (44.1%) 14 (70.0%) 24 (34.3%) 38 (42.2%) No 10 (33.3%) 47 (65.3%) 57 (55.9%) 6 (30.0%) 46 (65.7%) 52 (57.8%) Column total 30 (100%) 72 (100%) 102 (100%) 20 (100%) 70 (100%) 90 (100%) Significance p-value = 0.003 p-value = 0.004 Table 3: cross-tabulations showing the relationship between DOI and pN status in all cancers (n=102) and in cN0 cancers (n=90). DOI All patients (n=102) cN0 patient (n=90) pN+ pN0 Row total pN+ pN0 Row total > 4 mm 25 (83.3%) 50 (69.4%) 75 (73.5%) 17 (85.0%) 49 (70.0%) 66 (73.3%) ≤ 4 mm 5 (16.7%) 22 (30.6%) 27 (26.5%) 3 (15.0%) 21 (30.0%) 24 (26.7%) Column total 30 (100%) 72 (100%) 102 (100%) 20 (100%) 70 (100%) 90 (100%) Significance p-value = 0.147 p-value = 0.181 Table 4: sensitivity, specificity, PPV and NPV and accuracy of MET positivity and DOI > 4 mm with respect to pN+ for all cancers (n=102) and cN0 cancers (n=90). All patients (n=102) cN0 patients (n=90) Sens. (%) Spec. (%) PPV (%) NPV (%) Acc. (%) Sens. (%) Spec. (%) PPV (%) NPV (%) Acc. (%) MET positivity 66.7 65.3 44.4 82.5 65.7 70.0 65.7 36.8 88.5 66.7 DOI > 4mm 83.3 30.6 33.3 81.5 46.1 85.0 30.0 25.8 87.5 42.2 MET positivity and DOI as predictors for (pN+ and occult) LNM Univariable binary logistic regression showed that MET positivity is associated with pN+ status in general (OR = 3.76; 95% CI: 1.53 – 9.26, p-value < 0.05; Supplementary table 2) and for occult LNM (OR = 4.28; 95% CI: 1.45 – 12.65, p-value < 0.05; Supplementary table 2). DOI > 4 mm shows an OR of 2.20 for pN+ (95% CI: 0.745 – 6.50, p-value = 0.15; Supplementary table 3) and 2.43 for occult LNM (95% CI: 0.64 – 9.18, p-value = 0.19; Supplementary table 3). Multivariable analysis showed that MET positivity is independently associated with pN+ in general and occult LNM when corrected for DOI > 4 mm (Table 5).
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