243 General discussion, conclusion, and future perspective Besides investigating the functional activity of MET-EC-, it would be interesting to examine more closely which molecular mechanisms facilitate ectodomain shedding (e.g. GPCR transactivation of EGFR signaling, overexpression of ADAM10/17, and/ or tumor-stroma interactions). Besides creating a more profound understanding of the mechanisms underlying MET signaling and ectodomain shedding, such insights might generate new leads for targeted therapies. 8
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