273 List of abbreviations OS Overall survival PD-1 Programmed cell death protein PD-L1 Programmed cell-death ligand 1 Per. Periphery PI3K Phosphoinositide 3-kinase PKCα Protein kinase C alpha PKCε Protein kinase C epsilon Pos. Positive PPV(s) Positive predictive value(s) PS-RIP Presenilin-regulated intramembrane proteolysis pTR Pathological tumor response qRT-PCR Quantitative real-time polymerase chain reaction Rac1 Rac family small GTPase 1 RAS RAS protein (R)LNM(s) (Regional) lymph node metastasis(/es) ROC Receiver operating characteristic RTK Receptor tyrosine kinase SI(s) Staining intensity(/ies) Sens. Sensitivity SLNB Sentinel lymph node biopsy SOS Son of sevenless Spec. Specificity STAT(3) Signal transducer and activator of transcription (3) TKI(s) Tyrosine kinase inhibitor(s) TM Transmembranous TMA(s) Tissue microarray(s) TNM Tumor-node-metastasis Uni. Uniform Var. Variable WB Western blot WPOI Worse pattern of invasion WTS(s) Whole tissue section(s)
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