74 Chapter 3 Supplementary table S6: Evaluation of possible confounders and significant statistical interaction for 5-year OS. Explanatory variable 5-year OS Confounder Effect modifier b1 eq. 1 b1 eq. 2 Variation b1’s (%) exp{b3} eq. 3 p-value Sex 0.78 0.77 1.28 0.61 0.25 Age at diagnosis (years) 0.78 0.76 3.19 0.99 0.71 Smoking 0.80 0.78 1.88 1.21 0.69 Alcohol 0.80 0.81 -1.25 0.83 0.66 Site 0.78 0.78 0.38 0.39 0.24 cT-stage 0.78 0.67 14.43 0.63 0.27 cN-stage 0.78 0.74 5.87 0.58 0.19 pT-stage 0.78 0.69 12.26 0.70 0.41 pN-stage 0.78 0.80 -1.92 0.89 0.78 Infiltration depth 0.78 0.78 1.02 0.25 0.27 Differentiation grade 0.78 0.76 2.43 1.02 0.98 Vasoinvasive growth 0.81 0.74 8.17 0.30 0.01 Bone invasion 0.78 0.74 6.00 0.86 0.75 Perineural invasion 0.83 0.92 -11.86 1.73 0.21 Extranodal growth 0.77 0.60 22.15 0.54 0.14 Growth pattern 0.82 0.87 -6.50 1.08 0.90 Postoperative (C)RT 0.80 0.83 -4.65 0.36 0.06 Abbreviations: OS, Overall Survival; (C)RT, (chemo)radiotherapy; eq., equation. Bold values highlight statistical significance.
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