91 MET ECD shedding and poor DFS Table 1 (Continued) Definition of staining intensities and scores used to evaluate D1C2 and A2H2-3 immunoreactivity across the tissue microarray Cellular localization SI Description SI Score Description score Membrane 0 No staining Negative % of cancer cells having SIs of 0 and/or 1 1 Weak complete or incomplete membranous staining 2 Moderate complete membranous staining Positive % of cancer cells having SIs of 2 and/or 3 3 Strong complete membranous staining Evaluation of MET protein status across the tissue microarray Protein status Description MET protein status Negative <10% of cancer cells are positive for D1C2 and A2H2-3 MET decoy Average % of D1C2 positive cancer cells < average % of A2H2-3 positive cancer cells Transmembranous C-terminal MET having or not having the ectodomain Average % of D1C2 positive cells ≥ average % of A2H2-3 positive cancer cells Evaluation of MET ectodomain shedding across the tissue microarray Score ectodomain shedding Description score (Average % of D1C2 positive cancer cells)–(average % of A2H2-3 positive cancer cells) % of cancer cells that display shedding 4
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