TABLE OF CONTENTS Chapter 1 General introduction and outline of this thesis 7 Part 1 Chapter 2 Lesion detection by [89Zr]Zr-DFO-girentuximab and [18F]FDG PET/CT in patients with newly diagnosed metastatic clear cell renal cell carcinoma. EJNMMI 2019 23 Chapter 3 The value of [89Zr]Zr-DFO-girentuximab and [18F]FDG PET/CT to predict watchful waiting duration in patients with metastatic clear cell renal cell carcinoma. Clinical Cancer Research 2023 43 Part 2 Chapter 4 Programmed Cell Death-1/Ligand-1 PET Imaging: A Novel Tool to Optimize Immunotherapy? Pet Clinics 2020 67 Chapter 5 [89Zr]Zr-DFO-durvalumab PET/CT before durvalumab treatment in patients with recurrent or metastatic head and neck cancer. Journal of Nuclear Medicine 2022 81 Chapter 6 [89Zr]Zr-DFO-avelumab PET/CT in early-stage non-small cell lung carcinoma patients to predict neo-adjuvant avelumab treatment response. Manuscript in preparation 111 Chapter 7 Towards a better understanding of immune checkpoint inhibitor in radiolabeled PET-imaging studies. Journal of Nuclear Medicine 2022 129 Chapter 8 Summary, general discussion and future perspectives 137 Chapter 9 Nederlandse samenvatting 151 Addendum List of publications 158 PhD portfolio 160 Research datamanagement 162 Dankwoord 164 Curriculum vitae 168
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