119 Echocardiographic changes in Fabry disease Results Participants’ characteristics Ninety-two classical FD patients (34 men and 58 women) were included (table 1). For each FD patient two echocardiograms were assessed (184 in total), with a median of 12 years (range 5-16 years) between them. The median age of FD patients at the first and the last obtained echocardiogram was 39 years (range: 18-72) and 51 years (range: 24-82) respectively. Ninety-two percent of the included FD patients have been treated with ERT, during a median period of 11 years (range: 1-21). ERT initiation decisions were based on FD symptoms [30] or recommendations by the European Fabry Working Group once available from 2015 onwards [31]. The subset of the Rotterdam study [24] consisted of 147 healthy control subjects (single measurement per subject) (50% men and 50% women) with a median age of 44 years (range: 20-72) at time of echocardiography. 4
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