125 Echocardiographic changes in Fabry disease Table 2: Echocardiographic morphological and functional parameters - estimated regression coefficients (β) per 10 years with 95%-CI Subgroups IVSd (mm) RWT (-) LVMi (g/m2) LAVI (ml/m2) E/e’ (-) Fabry men 1.8 (1.4-2.2)*** 0.1 (0.1-0.1)*** 26.2 (21.6-30.8)*** 8.0 (5.0-11.1)*** 3.1 (2.4-3.9)*** Healthy men 0.6 (0.2-0.9)** 0.02 (0.002- 0.04)* 0.8 (-3.4- 5.1) 0.1 (-2.6- 2.8) 0.4 (-0.2- 1.1) Fabry women 1.5 (1.2-1.8)*** 0.1 (0.1-0.1)*** 12.7 (9.5-16.0)*** 4.9 (2.5-7.2)*** 2.0 (1.5-2.6)*** Healthy women 0.7 (0.3-1.1)*** 0.02 (0.003-0.04)* 1.3 (-3.0- 5.6) 0.9 (-1.8-3.6) 0.7 (0.04-1.4)* Differences in regression coefficients (β) per 10 years between subgroups with 95%-CI Fabry men minus Fabry women 0.3 (-0.2- 0.8) 0.014 (-0.01- 0.04) 13.5 (7.8-19.1)*** 3.2 (-0.7-7.1) 1.1 (0.2-2.0)* Fabry men minus Healthy men 1.2 (0.7-1.7)*** 0.1 (0.03- 0.1)*** 25.4 (19.1-31.6)*** 8.0 (3.9- 12.0)*** 2.7 (1.6-3.7)*** Fabry women minus Healthy women 0.8 (0.3-1.2)** 0.1 (0.02-0.1)*** 11.4 (6.0-16.8)*** 4.0 (0.4-7.6)* 1.3 (0.4- 2.2)** Healthy men minus Healthy women -0.1 (-0.6- 0.4) 0.0 (0.0-0.0) -0.5 (-6.5- 5.6) -0.8 (-4.6- 3.1) -0.3 (-1.3- 0.7) * p< 0.05, ** p< 0.01, ***p<0.001 Diastolic interventricular septum thickness (IVSd), relative wall thickness (RWT), left ventricular mass index (LVMi), left atrium volume index (LAVI) and the ratio of early diastolic mitral inflow velocity/ early diastolic septal tissue mitral annulus velocity (E/e’). 4
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