128 Chapter 4 Figure 2: (continued) Morphological echocardiographic features IVSd and RWT IVSd and RWT increased significantly faster in FD patients compared to healthy control subjects (men: FD minus healthy controls β-IVSd= 1.2 mm per decade; 95%-CI 0.7-1.7, β-RWT= 0.1 per decade; 95%-CI 0.03-0.1, women: FD minus healthy controls β-IVSd= 0.8 mm per decade; 95%-CI 0.3-1.2, β-RWT= 0.1 per decade; 95%-CI 0.02-0.1) (table 2, figure 1A-1B). The increment in IVSd and RWT over time did not differ between men and women with FD, but male patients showed overall significantly higher IVSd values throughout follow-up (figure 1A-1B). From 30-39 years onwards, the absolute values for IVSd and RWT in men with FD became significantly higher compared to healthy men (figure 2). Women with FD showed a significantly higher value for IVSd from 18-29 years onwards as compared to healthy women, whilst this occurred a decade later for RWT. In men with FD, values increased to levels above references ranges (RWT> 0.42 and IVSd> 12 mm) from 30 years (RWT) and 40 years (IVSd) onwards, this occurred approximately a decade later in women with FD (figure 2A-2B, supplemental table 1).
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