130 Chapter 4 incomplete for 8 patients). Patients with FD showed LV diastolic dysfunction mainly from 40 years of life onwards and the proportion of patients with diastolic dysfunction increased over the following decades (figure 3). Both men and women with FD showed an increase in GLS evolution over time. Though formal comparison is not possible because of the use of different measurement algorithm in healthy control subjects and FD patients, GLS seems to increase more rapidly with ageing in FD patients compared to healthy control subjects (supplemental figure 5, supplemental table 3). Data on other echocardiographic features (biplane LV EF, TAPSE, SoV diameter and TR Vmax) can be found in the supplemental results section and supplemental figure 3-4.
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