137 Echocardiographic changes in Fabry disease SUPPLEMENTAL MATERIAL Supplemental results Biplane LV EF and TAPSE Between 50-60 years, a minority of the patients with FD (4/31 (13%) men and 4/53 (8%) women) developed on the last echocardiogram a LV EF< 50%. For the gross majority of FD patients, TAPSE remained within the normal range (>1.6 cm). On the last echocardiography, 2/31 (7%) men with FD had an abnormal TAPSE after 40 years, while women with FD developed these abnormalities at a comparable frequency (5/57 (9%)) about 10 years later. See supplemental figure 3 and supplemental table 3 for the detailed data visualization and descriptives, respectively. SoV diameter and TR Vmax (only assessed in FD patients) A slight increase in SoV diameter over the ages was observed throughout the follow-up in both men and women. Values for SoV diameter increase to levels outside of the relevant references range (> 40 mm in men and >36 mm in women) after 20 years in men and after 40 years in women. The TR Vmax did not show a clear increasing or decreasing trend in time, wherein the majority of the FD patients also revealed a normal TR V max (<2.8 cm/s), even at an older age. See supplemental figure 4 and supplemental table 3 for the detailed data visualization and descriptives. 4
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