140 Chapter 4 Supplemental table 2A: GLM of the echocardiographic morphological parameters IVSd (mm) RWT (-) LVMi (g/m2) LAVI (ml/m2) Model 1 (age, subject type and sex separated) Fixed effects β (95% CI) p value β (95% CI) p value β (95% CI) p value β (95% CI) p value Age 0.09 0.07 – 0.11 <0.001 0.004 0.003 – 0.005 <0.001 0.51 0.21 – 0.80 0.001 0.30 0.16 – 0.44 <0.001 Type (FD patient) 2.39 1.77 – 3.01 <0.001 0.08 0.05 – 0.11 <0.001 33.13 26.31 – 39.95 <0.001 0.10 -2.90 – 3.09 0.950 Sex (Male) 1.17 0.57 – 1.78 <0.001 0.02 -0.01 – 0.05 0.110 11.68 4.40 – 18.95 0.002 2.29 -0.71 – 5.28 0.134 Model 2 (healthy and FD patients combined groups- with age*subject type*sex interactions) (Intercept) 5.41 3.84 – 6.99 0.26 0.18 – 0.34 58.81 40.29 – 77.34 25.88 15.06 – 36.71 Age 0.07 0.03 – 0.11 <0.001 0.002 0.0002 – 0.004 0.027 0.13 -0.30 – 0.56 0.549 0.09 -0.18 – 0.36 0.528 Type (FD patient) -0.50 -2.45 – 1.46 0.616 -0.09 -0.19 – 0.01 0.081 -14.07 -37.02 – 8.89 0.229 -18.14 -32.39 – -3.88 0.013 Sex (Male) 1.88 -0.31 – 4.08 0.092 0.04 -0.08 – 0.15 0.497 7.11 -18.72 – 32.94 0.588 1.42 -13.74 – 16.57 0.854 Interactions Age*Type (FD patient) 0.08 0.03 – 0.12 0.001 0.01 0.002 – 0.01 <0.001 1.14 0.60 – 1.68 <0.001 0.40 0.04 – 0.76 0.030 Age*Sex (Male) -0.01 -0.06 – 0.04 0.668 -0.0002 -0.003 – 0.002 0.854 -0.05 -0.65 – 0.56 0.881 -0.08 -0.46 – 0.31 0.690 Type (FD patient)*Sex (Male) -1.01 -3.85 – 1.84 0.486 -0.03 -0.18 – 0.12 0.679 -20.19 -53.58 – 13.20 0.235 -4.49 -25.44 – 16.45 0.673 Age*Type (FD patient)*Sex (Male) 0.04 -0.028 – 0.11 0.240 0.0016 -0.002 – 0.006 0.402 1.39 0.56 – 2.22 0.001 0.40 -0.15 – 0.94 0.153
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