141 Echocardiographic changes in Fabry disease Supplemental table 2B: GLM of the echocardiographic functional parameters E/e’ (-) Model 1 (age, subject type and sex separated) Fixed effects β (95% CI) p value Age 0.12 0.08 – 0.16 <0.001 Type (FD patient) 2.88 1.97 – 3.78 <0.001 Sex (Male) -0.60 -1.54 – 0.34 0.210 Model 2 (healthy and FD patients combined groups- with age*subject type*sex interactions) (Intercept) 4.59 1.71 – 7.47 Age 0.07 0.00 – 0.14 0.038 Type (FD patient) -1.21 -4.80 – 2.37 0.506 Sex (Male) 0.74 -3.24 – 4.72 0.715 Interactions Age*Type (FD patient) 0.13 0.04 – 0.22 0.005 Age*Sex (Male) -0.03 -0.13 – 0.07 0.560 Type (FD patient)*Sex (Male) -3.77 -8.95 – 1.42 0.154 Age*Type (FD patient)*Sex (Male) 0.14 0.00 – 0.27 0.044 4
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