163 Plasma globotriaosylsphingosine and the natural Fabry disease course Figure 1: LysoGb3 in individual untreated FD patients over time. Only patients with at least 2 separate untreated measurements are displayed to visualize change over time. The earliest measurements were at the age of 3 years. (a) Patients aged 3-20 years (n= 36). (b) Patients aged 21-40 years (n=36). (c) Patients aged 41-60 years (n=40). (d) Patients aged 61-80 years (n=11). Colored lines represent individual patients. 5
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