Table of contents Chapter 1 9 General introduction and thesis outline Chapter 2 23 Influence of sex and phenotype on cardiac outcomes in patients with Fabry disease Chapter 3 61 ECG Changes During Adult Life in Fabry Disease: Results from a Large Longitudinal Cohort Study Chapter 4 111 Early echocardiography markers of Fabry cardiomyopathy identified in a multi-decade longitudinal cohort study Chapter 5 155 Early risk stratification for natural disease course in Fabry patients using plasma globotriaosylsphingosine levels Chapter 6 183 Summary and general discussion Appendices 205 Dutch summary (Nederlandse samenvatting) 206 Arabic summary 210 Contributing authors’ affiliations 213 Portfolio 215 Curriculum vitae 217 Dankwoord 218
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