51 Cardiac outcomes in Fabry disease Supplemental table 2: Prevalence, event rates and age at onset of individual outcomes † (continued) All (213) Men (83) Women (130) Classical (57) Non-classical (26) Classical (98) Non-classical (32) 7. Sinusarrest Number of patients 7 (3%) 3 (5%) 2 (8%) 2 (2%) 0 (0%) Event rate, with 95%-CI 1.0 (0.4-2.0) 1.9 (0.5-5.3) 1.7 (0.3-5.6) 0.6 (0.1-2.1) 0 (-) Age at first documentation 58 (48-69) 58 (48-60) 60 (58-62) 59 (49-69) (-) 8. PM, ICD and CRT-D implantation Number of patients 36 (17%) 9 (16%) 11 (42%) 14 (14%) 2 (6%) PM 14 (7%) 4 (7%) 3 (12%) 5 (5%) 2 (6%) PM + ICD upgrade at later stage 3 (1%) 0 (0%) 2 (8%) 1 (1%) 0 (0%) ICD 7 (3%) 0 (0%) 3 (12%) 4 (4%) 0 (0%) DDD-ICD 9 (4%) 3 (5%) 2 (8%) 4 (4%) 0 (0%) CRT-D 2 (1%) 2 (4%) 0 (0%) 0 (0%) 0 (0%) PM + CRT-D upgrade at later stage 1 (0.5%) 0 (0%) 1 (4%) 0 (0%) 0 (0%) 9. Coronary artery disease Number of patients 18 (9%) 9 (16%) 3 (12%) 6 (6%) 0 (0%) Event rate, with 95%-CI 2.5 (1.6-3.9) 5.8 (2.8-10.7) 2.5 (0.6-6.9) 1.9 (0.8-3.9) 0 (-) Age at first documentation 55 (39-77) 51 (46-64) 55 (53-67) 57 (39-77) (-) 10. Percutaneous coronary intervention Number of patients 7 (3%) 3 (5 %) 2 (8%) 2 (2%) 0 (0%) Event rate, with 95%-CI 1.0 (0.4-2.0) 1.9 (0.5-5.3) 1.7 (0.3-5.6) 0.6 (0.1-2.1) 0 (-) Age at first documentation 53 (39-67) 50 (48-64) 61 (55-67) 46 (39-53) (-) 11. Coronary artery bypass graft surgery Number of patients 4 (2%) 3 (5%) 1 (4%) 0 (0%) 0 (0%) Event rate, with 95%-CI 0.6 (0.2-1.4) 1.9 (0.5-5.3) 0.8 (0.04-4.1) 0 (-) 0 (-) Age at first surgery 58 (54-69) 58 (54-58) 69 (-) (-) 2
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