53 Cardiac outcomes in Fabry disease Supplemental table 3: Classification of myocardial infarctions All (213) Men (83) Women (130) Classical (57) Non-classical (26) Classical (98) Non-classical (32) Type I, n 7 3 1 3 0 STEMI, n 3 1 1 1 - NSTEMI, n 3 1 0 2 - Unknown, n 1 1 0 0 - Type II, n 5 2 0 3 0 NSTEMI, n 5 2 - 3 - Unknown type of infarction, n 10 3 3 4 0 NSTEMI, n 4 1 1 2 - Unknown, n 6 2 2 2 - n = number of patients; STEMI = ST-segment elevation myocardial infarction; NSTEMI = NonST-segment elevation myocardial infarction. Supplemental table 4: Patient kidney characteristics All (213) Men (83) Women (130) Classical (57) Nonclassical (26) Classical (98) Nonclassical (32) KDIGO CKD stages** Patients with a known CKD stage, n (%) 152 (71%) 41 (72%) 13 (50%) 82 (84%) 16 (50%) G1 (eGFR >90), n (%) 75 (49%) 23 (56%) 3 (23%) 37 (45%) 12 (75%) G2 (eGFR 60-89), n (%) 48 (32%) 9 (22%) 4 (31%) 33 (40%) 2 (13%) G3a (eGFR 45-59), n (%) 13 (9%) 1 (2%) 2 (15%) 8 (10%) 2 (13%) G3b (eGFR 30-44), n (%) 12 (8%) 7 (17%) 2 (15%) 3 (4%) 0 (0%) G4 (eGFR 15-29), n (%) 3 (2%) 1 (2%) 1 (8%) 1 (1%) 0 (0%) G5 (eGFR <15), n (%) 1 (1%) 0 (0%) 1 (8%) 0 (0%) 0 (0%) Proteinuria (microalbuminuria > 300 milligrams/ 24 hours)** Patients with a known proteinuria status, n (%) 71 (33%) 16 (28%) 7 (27%) 41 (42%) 7 (22%) Present proteinuria, n (%) 12 (17%) 4 (25%) 3 (43%) 5 (12%) 0 (0%) Absent proteinuria, n (%) 59 (83%) 12 (75%) 4 (57%) 36 (88%) 7 (100%) KDIGO= Kidney Disease Improving Global Outcomes; CKD= Chronic Kidney Disease; eGFR= estimated Glomerular Filtration Rate, according to the Chronic Kidney Disease Epidemiology Collaboration equation and measured in milliliters/ minute per 1.73 meter2 ** The KDIGO CKD and proteinuria status are measurements, which are known at the time of the last follow-up (with a minimum and maximum range of 1 year between the measurement and the last follow-up date). 2
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