71 ECG changes in Fabry disease Table 2A: Conduction times- estimated regression coefficients (β) per 10 years increase in age in each study participants subgroup with 95%-CI (based on the GLM) Participants subgroup P-wave duration (ms) PR-interval (ms) QRS-duration (ms) QTc (ms) FD men 2.9 (1.7-4.2)*** 2.3 (-1.0-5.5) 10.5 (8.9-12.0)*** 20.8 (18.1-23.5)*** Controls- men 3.2 (2.7-3.6)*** 3.6 (2.7-4.5)*** -0.6 (-1.1- -0.2)** 4.4 (3.4-5.3)*** FD women 5.0 (4.0-5.9)*** 10.4 (7.9-12.9)*** 9.3 (8.0-10.5)*** 12.6 (10.5-14.8)*** Controls- women 2.6 (2.2-2.9)*** 3.3 (2.6-4.0)*** 0.3 (-0.1-0.7) 4.4 (3.7-5.1)*** Estimated differences in regression coefficients (β) per 10 years increase in age between study participants subgroups with 95%-CI FD men minus FD women -2.1 (-3.6- -0.5)* -8.2 (-12.3- -4.1)*** 1.2 (-0.8-3.2) 8.2 (4.7-11.6)*** FD men minus Controls- men -0.2 (-1.6- 1.1) -1.3 (-4.7- -2.1) 11.1 (9.4- 12.7)*** 16.4 (13.6-19.3)*** FD women minus Controls- women 2.4 (1.4-3.4)*** 7.1 (4.5-9.7)*** 9.0 (7.7-10.2)*** 8.2 (6.0-10.5)*** Controls- men minus Controls- women 0.6 (0.001-1.1)* 0.3 (-0.9- 1.4) -0.9 (-0.15- -0.3)** 0.0 (-0.11-0.12) * p< 0.05, ** p< 0.01, ***p<0.001 Table 2B: Other LV ECG parameters- estimated regression coefficients (β) per 10 years increase in age in each study participants subgroup with 95%-CI (based on the GLM) Participants subgroup Cornell index (mm) Spatial QRS-T angle (°) Frontal QRS-axis (°) FD men 2.6 (1.9-3.4)*** 29.4 (26.1-32.6)*** -15.5 (-19.7- -11.2)*** Controls- men 0.0 (-0.2-0.3) 4.3 (3.3-5.3)*** -9.4 (-10.7- -8.1)*** FD women 1.8 (1.3-2.4)*** 27.7 (25.2-30.2)*** -11.4 (-14.6- -8.2)*** Controls- women 0.6 (0.4-0.8)*** 3.7 (2.9-4.5)*** -7.4 (-8.4- -6.3)*** Estimated differences in regression coefficients (β) per 10 years increase in age between study participants subgroups with 95%-CI FD men minus FD women 0.8 (-0.1-1.7) 1.7 (-2.4-5.8) -4.1 (-9.4- 1.3) FD men minus Controls- men 2.6 (1.8-3.4)*** 25.1 (21.7-28.5)*** -6.1 (-10.5- -1.6)** FD women minus Controls- women 1.2 (0.7-1.8)*** 24.0 (21.4-26.6)*** -4.0 (-7.4- -0.6)* Controls- men minus Controls- women 0.6 (0.3-0.9)*** 0.6 (0.7-1.9) -2.0 (-3.7- -0.4)* * p< 0.05, ** p< 0.01, ***p<0.001 3
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