79 ECG changes in Fabry disease Figure 4: (continued) P-wave duration and PR-interval In all subgroups, P-wave duration increased significantly with increasing age. Women with FDshowed a greater increment in P-wave duration with age compared to women controls (women: FD minus healthy controls β=2.4 ms per decade; 95%-CI 1.4-3.4) and compared to men with FD (FD: women minus men β=2.1 ms per decade; 95%-CI 0.5-3.6). In men, the increase in P-wave duration with ageing was similar for FD patients and control subjects (table 2A, figure 1A). In patients with FD, the absolute values for P-wave duration were significantly longer in men between age 40-50 years and in women between age 50-60 years compared to control subjects. These differences were not significant in the decades thereafter, but the number of observations in these later decades was low (figure 3A). P-wave duration showed median values above the normal range of 120 ms from 30-40 years in FD men and 50-60 years in FD women onwards (supplemental table 2, figures 3A). PR-interval significantly increased with ageing in both control groups and in women with FD, but not in men with FD (table 2A). In women, PR-interval showed a significantly faster prolongation with age in women with FD as compared to healthy controls (women: FD- controls β=7.1 ms per decade; 95%-CI 4.5-9.7), whilst in men with FD vs men controls this difference was not significant. In line with this observation, women with FD had a significantly faster prolongation with age compared to men with FD (FD: women-men β= 8.2 3
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