89 ECG changes in Fabry disease SUPPLEMENTAL MATERIAL Supplemental table 1A: Generalized linear mixed model of the conduction times P-wave duration (ms) PR-interval (ms) QRS-duration (ms) QTc (ms) Model 1 (age, Type and Sex separated) Fixed effects β (95% CI) p value β (95% CI) p value β (95% CI) p value β (95% CI) p value Age 0.28 0.25 – 0.31 <0.001 0.38 0.32 – 0.43 <0.001 0.059 0.02 – 0.0 0.001 0.54 0.49 – 0.60 <0.001 Type (FD patient) 1.40 0.02 – 2.77 0.046 -14.65 -18.00 – -11.30 <0.001 2.92 1.35 – 4.48 <0.001 -1.18 -3.82 – 1.46 0.381 Sex (Male) 6.94 6.21 – 7.67 <0.001 8.54 7.09 –9.99 <0.001 9.93 9.23 – 10.62 <0.001 -8.84 -10.33 – -7.36 <0.001 Model 2 (Controls and FD patients combined groups- with age*Type*Sex interactions) (Intercept) 96.62 95.00 – 98.23 140.30 136.94 – 143.66 90.91 89.30 – 92.53 401.60 398.23 – 404.97 Age 0.26 0.22 – 0.29 <0.001 0.33 0.26 – 0.40 <0.001 0.03 -0.01 – 0.07 0.114 0.44 0.37 – 0.51 <0.001 Type (FD patient) -7.407 -12.02 – -2.7 0.002 -43.83 -55.51 – -32.14 <0.001 -34.51 -39.91 – -29.12 <0.001 -38.99 -49.24 – -28.74 <0.001 Sex (Male) 4.55 1.95 – 7.15 0.001 7.10 1.75 – 12.46 0.009 13.27 10.70 – 15.83 <0.001 -9.09 -14.48 – -3.70 0.001 Interactions Age*Type (FD patient) 0.24 0.14 – 0.34 <0.001 0.71 0.45 – 0.97 <0.001 0.90 0.77 – 1.02 <0.001 0.82 0.60 – 1.05 <0.001 Age*Sex (Male) 0.06 0.00 – 0.11 0.045 0.03 -0.09 – 0.14 0.653 -0.09 -0.15 – -0.03 0.002 -0.01 -0.12 – 0.11 0.904 Type (FD patient)*Sex (Male) 11.44 4.29 – 18.59 0.002 39.40 21.08 – 57.71 <0.001 0.89 -7.56 – 9.34 0.837 -20.13 -36.05 – -4.20 0.013 Age*Type (FD patient)*Sex (Male) -0.26 -0.43 – -0.10 0.002 -0.84 -1.27 – -0.42 <0.001 0.21 0.00 – 0.42 0.049 0.82 0.46 – 1.19 <0.001 3
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