90 Chapter 3 Supplemental table 1B: Generalized linear mixed model of the other LV related ECG parameters Cornell index (mm) Spatial QRS-T angle (°) Frontal QRS-axis (°) Model 1 (age, Type and Sex separated) Fixed effects β (95% CI) p value β (95% CI) p value β (95% CI) p value Age 0.04 0.02 – 0.05 <0.001 0.53 0.47 – 0.60 <0.001 -0.84 -0.92 – -0.77 <0.001 Type (FD patient) 8.22 7.40 – 9.03 <0.001 35.91 32.10 – 39.73 <0.001 -6.82 -12.06 – -1.58 0.011 Sex (Male) 3.39 2.98 – 3.80 <0.001 5.07 3.33 – 6.80 <0.001 -3.93 -6.05 – -1.80 <0.001 Model 2 (Controls and FD patients combined groups- with age*Type*Sex interactions) (Intercept) 7.94 7.05 – 8.82 28.73 25.17 – 32.30 77.72 72.99 – 82.44 Age 0.06 0.04 – 0.08 <0.001 0.37 0.29 – 0.45 <0.001 -0.74 -0.84 – -0.63 <0.001 Type (FD patient) 2.87 0.22 – 5.51 0.034 -57.61 -69.01 – -46.21 <0.001 5.00 -10.16 – 20.16 0.518 Sex (Male) 5.95 4.54 – 7.37 <0.001 3.63 -2.08 – 9.34 0.213 4.42 -3.11 – 11.96 0.250 Age*Type (FD patient) 0.12 0.07 – 0.18 <0.001 2.40 2.14 – 2.66 <0.001 -0.40 -0.74 – -0.06 0.020 Age*Sex (Male) -0.06 -0.09 – -0.03 <0.001 0.06 -0.07 – 0.19 0.344 -0.20 -0.37 – -0.04 0.017 Type (FD patient)*Sex (Male) -4.25 -8.33 – -0.17 0.041 -8.01 -25.69 – 9.68 0.375 8.42 -15.54 – 32.39 0.491 Age*Type (FD patient)*Sex (Male) 0.14 0.04 – 0.23 0.005 0.11 -0.32 – 0.54 0.619 -0.20 -0.76 – 0.36 0.477
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