91 ECG changes in Fabry disease Supplemental table 1C: Conduction times - estimated regression coefficients (β) per 10 years increase in age in ERT treated versus ERT treated and untreated FD patients with 95%-CI (based on the GLM) ERT treated P-wave duration (ms) PR-interval (ms) QRS-duration (ms) QTc (ms) FD men 2.7 (1.5-4.0)*** 2.1 (-1.2-5.4) 10.9 (9.3-12.4)*** 20.8 (18.0-23.5)*** FD women 5.3 (4.2-6.4)*** 12.4 (9.5-15.3)*** 10.1 (8.7- 11.5)*** 13.8 (11.3-16.2)*** ERT treated and untreated P-wave duration (ms) PR-interval (ms) QRS-duration (ms) QTc (ms) FD men 2.9 (1.7-4.2)*** 2.3 (-1.0-5.5) 10.5 (8.9-12.0)*** 20.8 (18.1-23.5)*** FD women 5.0 (4.0-5.9)*** 10.4 (7.9-12.9)*** 9.3 (8.0-10.5)*** 12.6 (10.5-14.8)*** * p< 0.05, ** p< 0.01, ***p<0.001 Supplemental table 1D:Other LV ECG parameters - estimated regression coefficients (β) per 10 years increase in age in ERT treated versus ERT treated and untreated FD patients with 95%-CI (based on the GLM) ERT treated Cornell index (mm) Spatial QRS-T angle (°) Frontal QRS-axis (°) FD men 2.8 (2.0-3.5)*** 29.7 (26.4-33.0)*** -16.2 (-20.6- -11.8)*** FD women 1.6 (1.0-2.2)*** 28.5 (25.6- 31.4)*** -11.9 (-15.6- -8.1)*** ERT treated and untreated Cornell index (mm) Spatial QRS-T angle (°) Frontal QRS-axis (°) FD men 2.6 (1.9-3.4)*** 29.4 (26.1-32.6)*** -15.5 (-19.7- -11.2)*** FD women 1.8 (1.3-2.4)*** 27.7 (25.2-30.2)*** -11.4 (-14.6- -8.2)*** * p< 0.05, ** p< 0.01, ***p<0.001 3
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