95 ECG changes in Fabry disease Cornell index in women (ms) Age category Available ECGs in Fabry women, n Fabry women Median (IQR) Available ECGs in Controls- women, n Controls- women Median (IQR) P- value 18-29 28 12 (9-14) 435 9 (6-12) 0.3 30-39 21 14 (9-20) 393 10 (7-13) 0.008** 40-49 34 21 (13-30) 463 9 (7-13) <0.001*** 50-59 38 20 (13-29) 519 10 (7-13) <0.001*** 60-69 16 20 (14-23) 405 13 (9-16) 0.003** 70+ 4 13 (6-19) 11 13 (10-14) 1.0 Spatial QRS-T angle in women (°) Age category Available ECGs in Fabry women, n Fabry women Median (IQR) Available ECGs in Controls- women, n Controls- women Median (IQR) P- value 18-29 28 29 (20-37) 435 37 (25-48) 0.1 30-39 21 31 (22-60) 393 38 (28-50) 1.0 40-49 34 148 (111-161) 463 42 (31-56) <0.001*** 50-59 38 154 (126-166) 519 47 (33-60) <0.001*** 60-69 16 151 (137-169) 405 49 (36-69) <0.001*** 70+ 4 157 (139-164) 11 54 (40-73) 0.03* Frontal QRS-axis in women (°) Age category Available ECGs in Fabry women, n Fabry women Median (IQR) Available ECGs in Controls- women, n Controls- women Median (IQR) P- value 18-29 28 47 (30-63) 434 64 (48-76) 0.008** 30-39 21 37 (21-46) 393 59 (37-71) 0.03* 40-49 34 32 (11-53) 463 55 (30-70) 0.002** 50-59 38 25 (4-46) 519 42 (18-63) 0.01* 60-69 16 21 (-4.0-42) 404 30 (8-52) 1.0 70+ 4 50 (1-92) 11 15 (7-20) 1.0 3
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