in the old building (n=10) and nearly all patients in the new building (107 out of 124, 86.3%), all patients included on the ICU were excluded for further analysis (Fig. 1). After exclusions, 225 out of 379 (59.4%) patients in the old building, and 372 out of 776 (47.9%) patients in the new building were included (Fig. 1). In total, 511 patients were missed at discharge and received a self-sample request at their home address. Two-hundred and sixty (50.9%) patients returned a sample, with a median return time of eight days (2-45), 251 (49.1%) patients did not return a sample and were consequently excluded. Fifteen patients were included multiple times. In the old building, four patients were admitted twice, and in the new building eight patients were included twice and three patients were included three times. Four patients were admitted during the relocation of the hospital and were thus included in both the old and the new building. The majority of patients were admitted to a surgical department, 161 (71.6%) patients in the old building and 187 (50.2%) in the new building (Table 1). The proportion of patients admitted to a medical, surgical, and hematology specialization differed between the old building and the new hospital building (15.1 vs 21.2%, 71.5 vs 50.3%, and 13.3 vs 28.5%, respectively). Univariate analyses showed no statistically significant differences in patient characteristics of patients admitted to the old building and the new building (Table 1). Carriage and acquisition of ESBL-producing Enterobacterales Fifty-one out of 597 (8.5%) patients had at least one study sample positive for an ESBL-E, 16 out of 225 (7.1%) patients in the old building and 35 out of 372 (9.4%) patients in the new building (P=0.330). Thirty-four patients were ESBL-E colonized at admission, 10 (4.4%) patients in the old building, compared to 24 (6.5%) in the new building (P=0.305) (Table 2). Eleven out of 34 (32.4%) patients had been hospitalized in our hospital during the previous year, 23 (67.6%) patients were not hospitalized. Twelve patients, five (9.8%) in the old hospital building and 7 (13.7%) in the new hospital building, were positive at admission, but negative at discharge (P=0.774). In total, 20 (3.4%) patients, seven (3.1%) in the old building and 13 (3.5%) in the new building, acquired an ESBL-E during hospitalization (P=0.801) (Table 2). In total, 17 (3.0%) patients, six (2.7%) patients in the old building and 11 (3.0%) in the new building, were positive only at discharge. Additionally, one patient in the old building and one patient in the new building were positive for a different ESBL-E at discharge and one patient in the new building acquired an additional ESBL-E. E. coli and K. pneumoniae were most prevalent, at admission and discharge, and were also the ESBL-E most often acquired. 2 31 Effect of single-occupancy rooms on ESBL-E acquisition
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